abstract：BACKGROUND:The diversity of malignant salivary gland tumors challenges the study of survival rates. The current study evaluated patient survival rates using Kaplan-Meier analysis and examined the relative effects of histology, grade and stage on survival. MATERIALS AND METHODS:Using the Kaplan-Meier model, cancer-spec...

journal_title：Anticancer research

authors： Israel Y,Rachmiel A,Gourevich K,Nagler R

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND/AIM:Hepatitis B virus-encoded X protein (HBx) plays a pivotal role in hepatocellular carcinoma (HCC) progression and treatment resistance. Interestingly, our previous study unexpectedly showed that full-length HBx sensitized HCC cells to lapatinib by up-regulating erb-b2 receptor tyrosine kinase 3 (ERBB3). W...

journal_title：Anticancer research

authors： Chen JY,Huang WC,Wei CT,Chien PH,Chen YJ

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND/AIM:Few data are available on the utility of definitive radiation therapy (RT) for pediatric craniopharyngioma. This study sought to evaluate practice patterns and patient outcomes using the Surveillance Epidemiology and End Results database from 2004-2014. MATERIALS AND METHODS:Overall survival (OS) was co...

journal_title：Anticancer research

authors： Hill TK,Baine MJ,Verma V,Alam M,Lyden ER,Lin C,Connolly EP,Zhang C

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND/AIM:The combination of bevacizumab (BEV) plus interferon alpha-2a (IFN) constitutes an option for first-line treatment of metastatic renal cell carcinoma. Real-world data from routine clinical practice are rare and were, therefore, collected during this non-interventional study (NIS). PATIENTS AND METHODS:A...

journal_title：Anticancer research

authors： Schultze-Seemann W,Schulz H,Tschechne B,Häckl M

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND/AIM:Advanced anaplastic thyroid cancer (ATC) is a rare, but highly aggressive malignancy, and its prognostic factors need to be further explored. We examined socioeconomic factors' predictive effect for survival performance in stage IV ATC patients. MATERIALS AND METHODS:Using the Surveillance, Epidemiology...

journal_title：Anticancer research

authors： Li MU,Gu S,Mao R,Ning Y,Trivedi N,Siddiqui A,Li P,Huo L

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND/AIM:Although reckoned necessary for survival benefit, neoadjuvant chemotherapy (NAC) of gastric cancer (GC) patients has so far provided questionable results. Consequently, searching for new and clearer systems of response to NAC, post-NAC re-evaluation and prognostic prediction appears essential. The purpos...

journal_title：Anticancer research

authors： Virgilio E,Giarnieri E,Giovagnoli MR,Montagnini M,Proietti A,D'Urso R,Fegiz A,Mercantini P,Balducci G,Cavallini M

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND/AIM:Several epidemiological studies have reported the chemopreventive potential of biochanin A, in cancer development and progression. We investigated the anticancer potential of combination of biochanin A and temozolomide against U-87 MG and T98 G [glioblastoma multiforme (GBM)] cells. MATERIALS AND METHOD...

journal_title：Anticancer research

authors： Desai V,Jain A,Shaghaghi H,Summer R,Lai JCK,Bhushan A

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND/AIM:The identification of a series of oxadiazole-based compounds, as promising antiproliferative agents, has been previously reported. The aim of this study was to explore the SAR of newly-synthesized oxadiazole derivatives and identify their molecular targets. MATERIALS AND METHODS:A small library of 1,2,5...

journal_title：Anticancer research

authors： Gelain A,Mori M,Meneghetti F,Porta F,Basile L,Marverti G,Asai A,Hyeraci M,García-Argáez AN,Via LD,Guccione S,Villa S

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND/AIM:Glioblastoma multiforme (GBM) is a malignant primary brain tumor with high rates of recurrence. This study aimed to investigate the effect of repurposed drug combinations on GBM. MATERIALS AND METHODS:Viability of U87 MG and 11ST patient-derived GMB cell lines, after valproic acid, tranylcypromine or ri...

journal_title：Anticancer research

authors： Sachkova A,Sperling S,Mielke D,Schatlo B,Rohde V,Ninkovic M

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:This was a validation study of a regional register of oral cancer in Örebro, Sweden. The purpose was to assess the rate of errors in baseline, and treatment, and the completeness and accuracy of data on recurrences. MATERIALS AND METHODS:A total of 653 cases with squamous cell cancer in the oral cavity were...

journal_title：Anticancer research

authors： Lundin E,Bergqvist M,Ahlgren J,Reizenstein J,Lennernäs BO

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND/AIM:This cross-sectional study estimated direct cancer-related health care, productivity and informal care costs for a six-month period for different states of breast cancer (BC). PATIENTS AND METHODS:A total of 827 BC patients answered a questionnaire enquiring about informal care, work capacity, and demog...

journal_title：Anticancer research

authors： Roine E,Färkkilä N,Sintonen H,Taari K,Roine RP,Saarto T

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND/AIMS:Our study aimed to compared 3-year results following laparoscopy-assisted proximal gastrectomy (LAPG)-double tract anastomosis (DTA) and lower esophageal sphincter-preserving LAPG (LES-LAPG). PATIENTS AND METHODS:Nine patients who underwent LES-LAPG and 23 LAPG-DTA were compared regarding 3-year follow...

journal_title：Anticancer research

authors： Kim DJ,Kim W

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND/AIM:To identify the clinical and dosimetric predictors of severe acute radiation esophagitis (RE) in patients with non-small cell lung cancer (NSCLC) treated with accelerated hyperfractionated concurrent chemoradiotherapy (AH-CCRT) with concomitant boost technique. PATIENTS AND METHODS:A total of 159 patien...

journal_title：Anticancer research

authors： Wada K,Kishi N,Kanayama N,Hirata T,Ueda Y,Kawaguchi Y,Morimoto M,Konishi K,Imamura F,Ogawa K,Teshima T

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Late developing breast cancer metastases are common and lethal despite treatment with adjuvant chemotherapy at the time of primary tumor excision. Stimulation of an antitumor immune response is an alternative strategy for preventing this devastating development. MATERIALS AND METHODS:A mouse model of the hu...

journal_title：Anticancer research

authors： Gao Y,Bergman I

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND/AIM:Cytological analysis for diagnosing malignant pleural effusion associated with lung adenocarcinoma (Ad-MPE) shows limited sensitivity and novel diagnostic biomarkers are needed. The aim of this study was to evaluate the profile of four microRNAs (miRNAs) in exosomes in Ad-MPE and benign (non-neoplastic) ...

journal_title：Anticancer research

authors： Tamiya H,Mitani A,Saito A,Ishimori T,Saito M,Isago H,Jo T,Yamauchi Y,Tanaka G,Nagase T

更新日期：2018-12-01 00:00:00

abstract：AIM:To investigate the relationship between erythrocyte sedimentation rate (ESR) and postoperative survival of patients with colorectal cancer (CRC). MATERIALS AND METHODS:Relationships between clinical characteristics and overall survival (OS) of patients with CRC were investigated using multivariate analysis. Receiv...

journal_title：Anticancer research

authors： Shibuya N,Ishizuka M,Takagi K,Iwasaki Y,Hachiya H,Aoki T,Kubota K

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND/AIM:The expression of metallothionein I/II (MT-I/II) was examined in thyroids of Graves' disease (GD) and nodular goiter (NG) patients to determine its role as a potential marker of proliferation and autoimmune inflammation in the thyroid. PATIENTS AND METHODS:MT-I/II and Ki-67 antigen expression was studie...

journal_title：Anticancer research

authors： Domoslawski P,Pula B,Olbromski M,Wojtczak B,Lukienczuk T,Podhorska-Okolow M,Dziegiel P

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND/AIM:Trans-hiatal and -cervical approach mediastinoscopic radical esophagectomy (TMrE) for esophageal cancers is a less-invasive procedure and does not require for trans-thoracic approach management. However, some patients suffer from pleural effusion after TMrE. In the present study, we investigated the clin...

journal_title：Anticancer research

authors： Hamada J,Konishi H,Shiozaki A,Fujiwara H,Shoda K,Kosuga T,Kubota T,Okamoto K,Arita T,Morimura R,Murayama Y,Ikoma H,Kuriu Y,Nakanishi M,Otsuji E

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND/AIM:NME/NM23 nucleoside diphosphate kinase 1 (NME1) is a metastasis suppressor gene, exhibiting reduced expression in metastatic cancers and the ability to suppress metastatic activity of cancer cells. We previously identified NME1-regulated genes with prognostic value in human melanoma. This study was condu...

journal_title：Anticancer research

authors： Pamidimukkala NV,Leonard MK,Snyder D,McCorkle JR,Kaetzel DM

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:It was recently reported that expression of prospero homeobox protein-1 (PROX1) is correlated with the prognosis of esophageal cancer and colorectal cancer. However, its correlation with gastric cancer is unclear. MATERIALS AND METHODS:Our study analyzed the effect of PROX1 knockdown on the migration, invas...

journal_title：Anticancer research

authors： Ueta K,Otowa Y,Kakeji Y,Hirashima M

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND/AIM:Breast cancer is the most prevalent and devastating malignant disease among women worldwide. Green tea has been extensively studied for its anti-cancer effects, however, existing literature on the correlation of other types of tea with breast cancer is very limited. MATERIALS AND METHODS:We used six dif...

journal_title：Anticancer research

authors： Shi H,Liu J,Tu Y,Freter CE,Huang C

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND/AIM:Recent studies implied a significant role of hypoxia-inducible factor-1α (HIF1α) in cell transformation. This study aimed to assess the effects of HIF1α on the epithelial-to-mesenchymal transition (EMT) and tumorigenesis of lung adenocarcinoma cells. MATERIALS AND METHODS:Invasion, migration and colony ...

journal_title：Anticancer research

authors： Liu KH,Tsai YT,Chin SY,Lee WR,Chen YC,Shen SC

更新日期：2018-11-01 00:00:00

abstract：AIM:To examine patterns of clinical practice in locally advanced esophageal cancer among US radiation oncologists after publication of the CROSS trial. MATERIALS AND METHODS:US radiation oncologists were surveyed on 13 questions pertaining to the management of esophageal cancer. Respondents' demographics and their cli...

journal_title：Anticancer research

authors： Elliott DA,Rana SR,Nabavizadeh N,Chen Y,Kusano A,Holland JM,Mitin T

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND/AIM:Hepatic venous isolation and extracorporeal charcoal hemoperfusion (HVI-CHP) can reduce systemic exposure to hepatic arterial infusion (HAI) chemotherapy. The pre-existing HVI-CHP system has limited effectiveness against high-dose cisplatin; therefore, we designed a new system and evaluated its efficacy ...

journal_title：Anticancer research

authors： So S,Komatsu S,Takebe A,Kido M,Tanaka M,Toyama H,Ueno K,Fukumoto T

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND/AIM:Few studies have examined postoperative CRP in esophageal cancer. We investigated the relationship between postoperative CRP values according to the postoperative period and prognosis in esophageal cancer. PATIENTS AND METHODS:We performed a retrospective cohort study including 187 patients who underwen...

journal_title：Anticancer research

authors： Katsurahara K,Shiozaki A,Fujiwara H,Konishi H,Kudou M,Shoda K,Arita T,Kosuga T,Morimura R,Murayama Y,Kuriu Y,Ikoma H,Kubota T,Nakanishi M,Okamoto K,Otsuji E

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Genetic alterations occurring in lung cancer are the basis for defining molecular subtypes and essential for targeted therapies. Exhaled breath condensate (EBC) is a form of non-invasive sample that, amongst components, contains DNA from pulmonary tissue. Next-generation sequencing (NGS) was herein used to a...

journal_title：Anticancer research

authors： Youssef O,Knuuttila A,Piirilä P,Böhling T,Sarhadi V,Knuutila S

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND/AIM:Inflammation is a key process in gastric carcinogenesis. Cytokines are mediators of inflammation and are involved in metastasis and tumorigenicity. We previously assessed the role of cytokine gene polymorphisms in gastric cancer risk in Chile. In the present study, we aimed to analyze whether these polym...

journal_title：Anticancer research

authors： Gonzalez-Hormazabal P,Romero S,Musleh M,Bustamante M,Stambuk J,Pisano R,Lanzarini E,Chiong H,Rojas J,Castro VG,Jara L,Berger Z

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND/AIM:The lipophilic, orally bioavailable camptothecin analogue gimatecan is characterized by improved efficacy over conventional camptothecins on human tumor xenografts. Gimatecan produced excellent outcomes orally with prolonged, low-dose, daily treatments. The aim of this study was to assess the antitumor e...

journal_title：Anticancer research

authors： DE Cesare M

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND/AIM:Chemotherapy-associated toxicity is one of the limiting factors regarding treatment efficacy, patient outcome and quality of life in this collective. Underweight or obese patients represent a major group in which the therapy seems to be more challenging. The aim of this analysis was to evaluate the impac...

journal_title：Anticancer research

authors： Grabowski JP,Richter R,Rittmeister H,Chekerov R,Woopen H,Sehouli J

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Kita-Kyushu lung cancer antigen-1 (KK-LC-1) is a cancer/testis antigen and predominant target for cancer immunotherapy. Its detection is only established based on gene expression. In this study, we established a monoclonal antibody against KK-LC-1 to detect its protein expression in formalin-fixed samples. ...

journal_title：Anticancer research

authors： Kondo Y,Fukuyama T,Yamamura R,Futawatari N,Ichiki Y,Tanaka Y,Nishi Y,Takahashi Y,Yamazaki H,Kobayashi N,Watanabe M

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND/AIM:The single nucleotide polymorphism -31C/G identified in the survivin gene promoter seems to be associated with over-expression of survivin, an anti-apoptotic protein. In gliomas, increased survivin expression correlated with decreased survival. The aim of the study was to investigate whether survivin gen...

journal_title：Anticancer research

authors： Kafadar D,Yaylim I,Kafadar AM,Cacina C,Ergen A,Kaynar MY,Isbir T

更新日期：2018-10-01 00:00:00

abstract：:Anaplastic lymphoma kinase (ALK) rearrangements were first implicated as driving mutations in non-small cell lung cancer in 2007. Since then, a number of novel, small-molecule inhibitors directed against the ALK receptor have demonstrated superiority over standard chemotherapies in the treatment of ALK rearrangement-p...

journal_title：Anticancer research

authors： Millett RL,Elkon JM,Tabbara IA

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND/AIM:High expression of the Bcl-2-interacting cell death suppressor (BIS), an anti-apoptotic protein, in various human cancers is linked to a poor outcome. The purpose of this study was to clarify whether BIS is associated with the migration and invasive characteristics of A549 cells. MATERIALS AND METHODS:B...

journal_title：Anticancer research

authors： Lee J,Yun HH,Kim S,Ji SH,Kuh HJ,Lee JH

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND/AIM:3,4',7-O-trimethylquercetin (34'7TMQ), a derivative of quercetin, inhibited ovarian cancer cell migration and invasion without affecting proliferation. In this study, the apoptotic effect of 34'7TMQ on three cancer cell lines (CRL-1978, CRL-11731, SK-OV-3) was evaluated. MATERIALS AND METHODS:Expression...

journal_title：Anticancer research

authors： Ashraf AHMZ,Afroze SH,Yamauchi K,Zawieja DC,Keuhl TJ,Erlandson LW,Uddin MN

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND/AIM:Pre-neoplastic lesions and renal cell tumors of distinct pheno- and genotypes occur frequently in end-stage kidneys. The aim of this study was to investigate the role of KRT7 and KRT19 in this process, the expression of which was previously detected by Affymetrix GeneChip analysis. PATIENTS AND METHODS:...

journal_title：Anticancer research

authors： Sarlos DP,Peterfi L,Szanto A,Kovacs G

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND/AIM:The aim of the study was to evaluate the necessity of gastrectomy including endoscopic submucosal dissection (ESD) scar with margin-negative early gastric cancer (EGC). PATIENTS AND METHODS:We analyzed 83 patients with EGC who received additional gastrectomy after non-curative ESD and evaluated the risk...

journal_title：Anticancer research

authors： Ishida R,Kanaji S,Maehara R,Hasegawa H,Yamamoto M,Matsuda Y,Yamashita K,Matsuda T,Oshikiri T,Sumi Y,Nakamura T,Suzuki S,Kakeji Y

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:A nodular lymphocyte predominant Hodgkin's lymphoma (NLPHL) is a lymphoproliferative neoplasm with a fair prognosis, but the possibility of a malignant transformation into a diffuse large B-cell lymphoma (DLBCL) is high. DLBCL progresses aggressively. Introduction of rituximab into therapy had led to improve...

journal_title：Anticancer research

authors： Gutsch J,Werthmann PG,Rosenwald A,Kienle GS

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:It is unclear whether radiomic phenotypes of brain metastases (BM) are related to radiation therapy prognosis. This study assessed whether a convolutional neural network (CNN)-based radiomics model which learned computer tomography (CT) image features with minimal preprocessing, could predict early response ...

journal_title：Anticancer research

authors： Cha YJ,Jang WI,Kim MS,Yoo HJ,Paik EK,Jeong HK,Youn SM

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND/AIM:This study's aim was to investigate the safety and effectiveness of asunaprevir and daclatasvir treatment for recurrent hepatitis C virus (HCV) infection in transplant recipients. The study cohort comprised 14 transplant recipients with recurrent hepatitis C who were receiving asunaprevir and daclatasvir...

journal_title：Anticancer research

authors： Harada N,Yoshizumi T,Ikegami T,Itoh S,Furusho N,Kato M,Shimoda S,Fukuhara T,Soejima Y,Maehara Y

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND/AIM:4H-1-Benzopyran-4-ones (chromones) provide a backbone structure for the chemical synthesis of potent anticancer drugs. In contrast to 2-(N-cyclicamino)chromones, the biological activity of 3-(N-cyclicamino)chromones has not been reported. In this study, cytotoxicity of 15 3-(N-cyclicamino)chromone deriva...

journal_title：Anticancer research

authors： Shi H,Nagai J,Sakatsume T,Bandow K,Okudaira N,Uesawa Y,Sakagami H,Tomomura M,Tomomura A,Takao K,Sugita Y

更新日期：2018-08-01 00:00:00